Ligand-based pharmacophore modeling and Bayesian approaches to identify c-Src inhibitors
نویسندگان
چکیده
منابع مشابه
Ligand-based pharmacophore modeling and Bayesian approaches to identify c-Src inhibitors.
Abstract Cellular Src (c-Src) kinases play a critical role in cell adhesion, proliferation, angiogenesis and cancer. Ligand-based pharmacophore models, used to identify the critical chemical features of c-Src inhibitors, were generated and validated by training, test and decoy sets, respectively. Best pharmacophore model, Hypo1, consists of four features such as HBA, HBD, Hy-Ar and RA. Hypo1 wa...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2013
ISSN: 1475-6366,1475-6374
DOI: 10.3109/14756366.2012.753881